発表論文
Comment on: Satoh-Asahara et al. Highly Purified Eicosapentaenoic Acid Increases Interleukin-10 Levels of Peripheral Blood Monocytes in Obese Patients With Dyslipidemia. Diabetes Care 2012;35:2631-2639.
Nonogaki K.
Diabetes Care. 2013 Jul;36(7):e109.
Low-frequency and very low-intensity ultrasound decreases blood pressure in subjects with hypertension.
Nonogaki K, Suzuki M, Sanuki M, Nonogaki N, Takeda K, Tsujita N, Katoh S, Kubota N.
Int J Cardiol. 2013. doi:pii: S0167-5273(13)00085-5. 10.1016/j.ijcard.2013.01.045.
Role of homeobox genes in the hypothalamic development and energy balance.
Kaji T, Nonogaki K.
Front Biosci. 2013；18:740-7.
Dysglycemia and cardiovascular risk.
Nonogaki K.
J Am Coll Cardiol. 2012;60:1121.
The relative contribution of hypothalamic neurons to the FoxO1-mediated regulation of feeding, body weight and hepatic glucose production.
Nonogaki K
Cell, http://www.cell.com/abstract/S0092-8674%2812%2900577-6#Comments
149,1314-1326, 2012.
Serotonin conflict in sleep-feeding.
Nonogaki K.
Vitam Horm. 2012;89:223-39.
Does serotonin actually increase sleep ?
Nonogaki K.
Cell 2011; http://www.cell.com/abstract/S0092-8674(11)00759-8#Comments
The contribution of serotonin 5-HT2C and melanocortin-4 receptors to the satiety signaling of glucagon-like peptide 1 and liragultide, a glucagon-like peptide 1 receptor agonist, in mice.
Nonogaki K, Suzuki M, Sanuki M, Wakameda M, Tamari T.
Biochem Biophys Res Commun. 2011 Jul 2. [Epub ahead of print]
Short-term effect of pitavastatin on the reactive hyperemic index in post-menopausal women with high levels in serum LDL-cholesterol.
Nonogaki K, Suzuki M, Kanai N, Sumii M, Kaji T.
Int J Cardiol. 2011 Jul 15;150(2):227-8. Epub 2011 Jun 2. No abstract available.
Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice.
Nonogaki K, Kaji T.
Int J Neuropsychopharmacol. 2010 Oct;13(9):1261-7. Epub 2010 Jun 29.
Contribution of central SGK-1 to the acute phase responses of mice to social isolation.
Kaji T, Nonogaki K.
Front Biosci (Elite Ed). 2010 Jun 1;2:1355-61.
Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice.
Nonogaki K, Kaji T, Ohba Y, Sumii M, Wakameda M, Tamari T.
Biochem Biophys Res Commun. 2009 Aug 21;386(2):311-5.
Novel modulators for body weight changes induced by fasting and re-feeding in mice.
Nonogaki K, Ohba Y, Sumii M, Wakameda M, Tamari T.
Biochem Biophys Res Commun. 2009 Jan 9;378(2):249-54.
Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene.
Nonogaki K, Ohba Y, Wakameda M, Tamari T.
Int J Neuropsychopharmacol. 2009 May;12(4):547-52.
5-HT and NA Reuptake Inhibitors and Appetite Regulation: The Role of the Central 5-HT Network.
Nonogaki K
Immun., Endoc. & Metab. Agents in Med. Chem., 2008, 8, 303-310
Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice.
Nonogaki K, Ohba Y, Sumii M, Oka Y.
Biochem Biophys Res Commun. 2008 Jul 18;372(1):186-90.
Ghrelin and feedback systems.
Nonogaki K.
Vitam Horm. 2008;77:149-70. Review.
Social isolation affects the development of obesity and type 2 diabetes in mice.
Nonogaki K, Nozue K, Oka Y.
Endocrinology. 2007 Oct;148(10):4658-66.
Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.
Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH.
J Neurosci. 2007 Jun 27;27(26):6956-64.
Isn't this just snacking? The potential adverse effects of night-eating symptoms on treatment adherence and outcomes in patients with diabetes: response to Morse et al.
Nonogaki K, Tateishi K, Nonogaki N.
Diabetes Care. 2007 May;30(5):e38; author reply e39.
Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice.
Nonogaki K, Nozue K, Kuboki T, Oka Y.
Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1775-81.
Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.
Nonogaki K, Nozue K, Takahashi Y, Yamashita N, Hiraoka S, Kumano H, Kuboki T, Oka Y.
Int J Neuropsychopharmacol. 2007 Oct;10(5):675-81.
Increased hypothalamic 5-HT2A receptor gene expression and effects of pharmacologic 5-HT2A receptor inactivation in obese Ay mice.
Nonogaki K, Nozue K, Oka Y.
Biochem Biophys Res Commun. 2006 Dec 29;351(4):1078-82.
Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice.
Nonogaki K, Nozue K, Oka Y.
Endocrinology. 2006 Dec;147(12):5893-900.
Induction of hypothalamic serum- and glucocorticoid-induced protein kinase-1 gene expression and its relation to plasma des-acyl ghrelin in energy homeostasis in mice.
Nonogaki K, Ohashi-Nozue K, Oka Y.
Biochem Biophys Res Commun. 2006 Jun 2;344(2):696-9.
A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice.
Nonogaki K, Ohashi-Nozue K, Oka Y.
Biochem Biophys Res Commun. 2006 Mar 17;341(3):703-7.
Clinical worth of adiponectin levels in obesity and glycemic control of Japanese type 2 diabetic patients.
Nonogaki K, Kumano H, Ootsuka Y, Takeuchi A, Nonogaki N, Kuboki T.
Diabetes Care. 2003 Nov;26(11):3198.
Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice.
Nonogaki K, Abdallah L, Goulding EH, Bonasera SJ, Tecott LH.
Diabetes. 2003 Feb;52(2):315-20.
Altered gene expressions involved in energy expenditure in 5-HT(2C) receptor mutant mice.
Nonogaki K, Memon RA, Grunfeld C, Feingold KR, Tecott LH.
Biochem Biophys Res Commun. 2002 Jul 12;295(2):249-54
Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice.
Memon RA, Tecott LH, Nonogaki K, Beigneux A, Moser AH, Grunfeld C, Feingold KR.
Endocrinology. 2000 Nov;141(11):4021-31.
New insights into sympathetic regulation of glucose and fat metabolism.
Nonogaki K.
Diabetologia. 2000 May;43(5):533-49. Review.
Obesity: autonomic circuits versus feeding.
Nonogaki K.
Nat Med. 1999 Jul;5(7):742-3.
Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene.
Nonogaki K, Strack AM, Dallman MF, Tecott LH.
Nat Med. 1998 Oct;4(10):1152-6.
Stress, acute hyperglycemia, and hyperlipidemia role of the autonomic nervous system and cytokines.
Nonogaki K, Iguchi A.
Trends Endocrinol Metab. 1997 Jul;8(5):192-7.
Role of central neural mechanisms in the regulation of hepatic glucose metabolism.
Nonogaki K, Iguchi A.
Life Sci. 1997;60(11):797-807. Review.
LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats.
Nonogaki K, Pan XM, Moser AH, Shigenaga J, Staprans I, Sakamoto N, Grunfeld C, Feingold KR.
Am J Physiol. 1996 Sep;271(3 Pt 1):E521-8.
Beta-nerve growth factor as a mediator of the acute phase response in vivo.
Nonogaki K, Moser AH, Shigenaga J, Feingold KR, Grunfeld C.
Biochem Biophys Res Commun. 1996 Feb 27;219(3):956-61.
Increase in insulin release from rat pancreatic islets by quinolone antibiotics.
Maeda N, Tamagawa T, Niki I, Miura H, Ozawa K, Watanabe G, Nonogaki K, Uemura K, Iguchi A.
Br J Pharmacol. 1996 Jan;117(2):372-6.
Keratinocyte growth factor increases fatty acid mobilization and hepatic triglyceride secretion in rats.
Nonogaki K, Pan XM, Moser AH, Staprans I, Feingold KR, Grunfeld C.
Endocrinology. 1995 Oct;136(10):4278-84.
Neuropeptide Y inhibits in vivo specific antibody production in rats.
Friedman EM, Irwin MR, Nonogaki K.
Brain Behav Immun. 1995 Sep;9(3):182-9.
Lipoteichoic acid stimulates lipolysis and hepatic triglyceride secretion in rats in vivo.
Nonogaki K, Moser AH, Pan XM, Staprans I, Grunfeld C, Feingold KR.
J Lipid Res. 1995 Sep;36(9):1987-95.
Interleukin-6 stimulates hepatic triglyceride secretion in rats.
Nonogaki K, Fuller GM, Fuentes NL, Moser AH, Staprans I, Grunfeld C, Feingold KR.
Endocrinology. 1995 May;136(5):2143-9.
Alpha-adrenergic receptors mediate the hypertriglyceridemia induced by endotoxin, but not tumor necrosis factor, in rats.
Nonogaki K, Moser AH, Feingold KR, Grunfeld C.
Endocrinology. 1994 Dec;135(6):2644-50.
Effects of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F2 alpha in rats.
Nonogaki K, Iguchi A, Sakamoto N.
Eur J Pharmacol. 1994 Sep 1;262(1-2):177-80.
Bicuculline methiodide influences the central nervous system to produce hyperglycemia in rats.
Nonogaki K, Iguchi A, Sakamoto N.
J Neuroendocrinol. 1994 Aug;6(4):443-6.
Effects of central GABA receptors activation on catecholamine secretion in rats.
Nonogaki K, Mizuno K, Sakamoto N, Iguchi A.
Life Sci. 1994;55(12):PL239-43.
Activation of central GABAA receptors suppresses the alteration of plasma catecholamine levels induced by neostigmine or histamine in rats.
Nonogaki K, Mizuno K, Sakamoto N, Iguchi A.
Life Sci. 1994;55(21):PL409-13.
CNS regulation of blood lactate concentration in anesthetized rats.
Watanabe G, Ishiguro T, Miura H, Uemura K, Hiyoshi Y, Ozawa K, Nonogaki K, Tamagawa T, Sakamoto N, Iguchi A.
Life Sci. 1994;54(20):1491-9.
Activation of GABAA receptors in hypothalamus modulates PGF2 alpha- or PGE2-induced catecholamine secretion in rats.
Nonogaki K, Mizuno S, Tamagawa T, Watanabe G, Sakamoto N, Iguchi A.
Prostaglandins. 1993 Feb;45(2):111-9.
Activation of GABAA receptor in the brain suppresses neostigmine or histamine-induced central nervous system-mediated hyperglycemia.
Nonogaki K, Li X, Ozawa K, Miura H, Watanabe G, Hiyoshi Y, Tamagawa T, Sakamoto N, Iguchi A.
Life Sci. 1993;53(9):PL159-63. Erratum in: Life Sci 1993;53(14):PL-235.
Intrahypothalamic, but not hippocampal, administration of muscimol suppresses hyperglycemia induced by hippocampal neostigmine in anesthetized rats.
Ozawa K, Miura H, Tamagawa T, Hiyoshi Y, Nonogaki K, Maeda N, Watanabe G, Sakamoto N, Iguchi A.
Life Sci. 1993;53(25):1903-9.
Involvement of central cholinergic muscarinic receptors and histamine H1 receptors in hyperglycemia induced by prostaglandin F2 alpha in rats.
Nonogaki K, Iguchi A, Zhu LX, Kunoh Y, Tamagawa T, Sakamoto N.
Neuroendocrinology. 1993 Jan;57(1):146-51.
Histamine-induced, central nervous system-mediated hyperglycemia is suppressed by atropine in the brain.
Nonogaki K, Li X, Tamagawa T, Watanabe G, Hiyoshi Y, Ozawa K, Sakamoto N, Iguchi A.
Life Sci. 1993;52(15):PL107-10.
Effects of the protein phosphatase inhibitors okadaic acid and calyculin A on insulin release from rat pancreatic islets.
Tamagawa T, Iguchi A, Uemura K, Miura H, Nonogaki K, Ishiguro T, Sakamoto N.
Endocrinol Jpn. 1992 Jun;39(3):325-9.
Effects of adrenergic blockers on central nervous system-mediated hyperglycemia in fed rats.
Kunoh Y, Iguchi A, Uemura K, Miura H, Tamagawa T, Mano T, Nonogaki K, Gotoh M, Sakamoto N.
Metabolism. 1992 May;41(5):471-5.
Mechanism of intrahippocampal neostigmine-induced hyperglycemia in fed rats.
Iguchi A, Uemura K, Miura H, Ishiguro T, Nonogaki K, Tamagawa T, Goshima K, Sakamoto N.
Neuroendocrinology. 1992 Jan;55(1):44-50.
Role of brain histamine H1- and H2-receptors in neostigmine-induced hyperglycemia in rats.
Nonogaki K, Iguchi A, Li X, Tamagawa T, Watanabe G, Hiyoshi Y, Sakamoto N.
Life Sci. 1992;51(12):PL131-4.
Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine.
Iguchi A, Uemura K, Kunoh Y, Miura H, Ishiguro T, Nonogaki K, Tamagawa T, Gotoh M, Sakamoto N.
Neuropharmacology. 1991 Oct;30(10):1129-31.
Relative contribution of nervous system and hormones to hyperglycemia induced by thyrotropin-releasing hormone in fed rats.
Ishiguro T, Iguchi A, Kunoh Y, Goto M, Uemura K, Miura H, Nonogaki K, Sakamoto N.
Neuroendocrinology. 1991 Jul;54(1):1-6.
Dissociation of hyperthermic and hyperglycemic effects of central prostaglandin F2 alpha.
Nonogaki K, Iguchi A, Yatomi A, Uemura K, Miura H, Tamagawa T, Ishiguro T, Sakamoto N.
Prostaglandins. 1991 May;41(5):451-62.
